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Hypoalbuminemia may correlate with severity of diarrhea because it results in a protein-losing enteropathy and albumin is considered a negative acute phase protein and a marker of inflammatory states. Accurate stratification of patients based upon severity of disease using these criteria will ensure adequate and timely institution of appropriate therapy without over-treating too many patients.
If unable to take metronidazole, vancomycin 125 mg orally four times a day for 10 days. A meta-analysis of 12 observational studies and randomized control trials (RCTs) showed that continued use of antimicrobials for infections other than CDI is significantly associated with an increased risk of CDI recurrence (47). In light of this consistent observational evidence, exposure to antibiotics other than those intended to treat CDI should be avoided unless absolutely indicated.